Product Areas
XPG Antibody
Product Details
Product Information
Source | Rabbit | Purification method | Antigen affinity purification |
Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
Calculated molecular weight |
1186aa,133 kDa |
Observed molecular
weight |
200 kDa |
GenBank accession number |
BC031522 | Gene ID (NCBI) | 2073 |
Gene symbol | ERCC5 | Synonyms | COFS3, ERCC5, ERCM2, UVDR, XPG, XPGC |
Background
The human genes correcting DNA repair defects are termed excision-repair cross-complementing or ERCC genes. The ERCC5 gene corrects the excision repair deficiency of Chinese hamster ovary cell line UV135 of complementation group 5. The human ERCC5 gene product is a structure-specific endonuclease required for making the 3-prime incision during DNA nucleotide excision-repair (NER). It also plays an important role in regulating DNA excision repair, removal of bulky lesions caused by environmental chemicals or UV light [PMID:22815677]. |