XPG Antibody

Product Details


Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Calculated molecular
weight
1186aa,133 kDa Observed molecular
weight
200 kDa
GenBank accession
number
BC031522 Gene ID (NCBI) 2073
Gene symbol ERCC5 Synonyms COFS3, ERCC5, ERCM2, UVDR, XPG, XPGC
Background

The human genes correcting DNA repair defects are termed excision-repair cross-complementing or ERCC genes. The ERCC5 gene corrects the excision repair deficiency of Chinese hamster ovary cell line UV135 of complementation group 5. The human ERCC5 gene product is a structure-specific endonuclease required for making the 3-prime incision during DNA nucleotide excision-repair (NER). It also plays an important role in regulating DNA excision repair, removal of bulky lesions caused by environmental chemicals or UV light [PMID:22815677].

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