Product Areas
XRN2 Antibody
Product Details
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
|
Calculated molecular weight |
104 kDa |
Observed molecular
weight |
104kd |
|
GenBank accession number |
BC006417 | Gene ID (NCBI) | 22803 |
| Gene symbol | XRN2 | Synonyms | XRN2, DHM1 like protein, DHP protein, 5' 3' exoribonuclease 2, 5 3 exoribonuclease 2 |
Background
XRN2 is one exonuclease that degrades the Pol II associated product of poly(A) site cleavage, which is crucial for Pol II termination. During transcription termination, XRN2 cleavages at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. |