Product Areas
ZIP kinase Antibody
Product Details
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | Peptide | Full name | death-associated protein kinase 3 |
|
Calculated molecular weight |
53 kDa |
Observed molecular
weight |
|
|
GenBank accession number |
NM_001348 | Gene ID (NCBI) | 1613 |
| Gene symbol | DAPK3 | Synonyms | DAP kinase 3, DAP like kinase, DAPK3, Dlk, ZIP kinase, ZIPK |
Background
ZIP kinase, also named as ZIPK and Dlk, belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and DAP kinase subfamily. ZIP kinase is a Serine/threonine kinase which acts as a positive regulator of apoptosis. ZIP kinasephosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. ZIP kinase regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. It catalyze the reaction: ATP + a protein = ADP + a phosphoprotein. |