Product Areas
NFIL3 Antibody
Product Details
Product Information
| Source | Mouse | Purification method | Protein G purification |
| Isotype | IgG1 | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
|
Calculated molecular weight |
462aa,51 kDa |
Observed molecular
weight |
50-55 kDa |
|
GenBank accession number |
BC008197 | Gene ID (NCBI) | 4783 |
| Gene symbol | NFIL3 | Synonyms | E4 promoter binding protein 4, E4BP4, IL3BP1, NF IL3A, NFIL3, NFIL3A |
Background
NFIL3, also named as E4BP4 and IL3BP1, belongs to the bZIP family and NFIL3 subfamily. It represses transcription from promoters with activating transcription factor (ATF) sites. NFIL3 activates transcription from the interleukin-3 promoter in T-cells. It competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). It is a component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. NFIL3 protects pro-B cells from programmed cell death. It is a key regulator of TH2 responses(PMID:21499227). |