Product Areas
NR2F6 Antibody
Product Details
Product Information
| Source | Mouse | Purification method | N/A |
| Isotype | IgG1 | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
|
Calculated molecular weight |
43 kDa |
Observed molecular
weight |
42 kDa |
|
GenBank accession number |
BC002669 | Gene ID (NCBI) | 2063 |
| Gene symbol | NR2F6 | Synonyms | EAR 2, EAR2, ERBAL2, NR2F6, V erbA related protein 2 |
Background
NR2F6 belongs to NR2F subfamily members, which have their roles in the regulation of neurogenesis, organogenesis, and cellular differentiation during embryonic development [PMID:15875024]. NR2F6 acts as transcription factor by binding to a TGACCT direct-repeat motif and has been established in controlling facets of central nervous system (CNS) [12690040]. It is a nuclear attenuator that directly interferes with DNA binding of NF-AT and, subsequently, transcriptional activity of the NF-AT-dependent IL-17 expression. Otherwise, NR2F6 negatively interfered with transcriptional cytokine responses and acted as a barrier against autoimmunity [PMID:18701084]. |