Product Areas
NUMB Antibody
Product Details
Product Information
| Source | Mouse | Purification method | Caprylic acid/ammonium sulfate precipitation |
| Isotype | IgG2a | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | peptide | Full name | numb homolog (Drosophila) |
|
Calculated molecular weight |
71 kDa |
Observed molecular
weight |
66-72 kDa |
|
GenBank accession number |
BC068476 | Gene ID (NCBI) | 8650 |
| Gene symbol | NUMB | Synonyms | h Numb, NUMB, numb homolog (Drosophila), Protein numb homolog, Protein S171, S171 |
Background
NUMB, also named as S171, plays a role in the determination of cell fates during development. It is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. The degradation of NUMB is induced in a proteasome-dependent manner by MDM2. Four transcript variants encoding different isoforms have been found for this gene. The antibody can bind to all these four isoforms P65, P66, P71 and P72, can’t recognize the NUMBL. |