p504S,AMACR Antibody
Product Details
| Source: | Mouse | Purify: | Protein G purification |
| IsoType: | IgG1 | Storage: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles. |
|
Caculated Molecular Weight: |
382aa,42 kDa |
Observed Molecular
Weight: |
42kd |
| GenbankNo | BC009471 | GeneID: | 23600 |
| Symbol | AMACR | Synonyms | AMACR, RACE, p504S, CBAS4, alpha methylacyl CoA racemase |
AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR(PMID:12213712). It has 3 isoforms produced by alternative splicing. Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) and congenital bile acid synthesis defect type 4 (CBAS4). |