PAIP1 Antibody

Product Details


Product Information
Source Mouse Purification method Caprylic Acid/Ammonium Sulfate Precipitation
Isotype IgG2b Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Calculated molecular
weight
70 kDa Observed molecular
weight
42+60+70+110 kDa
GenBank accession
number
BC005295 Gene ID (NCBI) 10605
Gene symbol PAIP1 Synonyms PABP interacting protein 1, PAIP 1, PAIP1
Background

In initiation of translation in eukaryotes, binding of the small ribosomal subunit to mRNA requires recognition of the 5-prime cap structure by the cap-binding complex eIF4F. eIF4F consists of eIF4E, eIF4A, and eIF4G. Translation initiation is further regulated by the mRNA 3-prime poly(A) tail and the poly(A)-binding protein (PABC1). PAIP1 interacts with PABC1 and some eIF4 complexes [PMID:9548260]. It is a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs, and associates with EIF4A and PABPC1 may potentiate contacts between mRNA termini [PMID:11051545].

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