Product Areas
PAIP1 Antibody
Product Details
Product Information
Source | Mouse | Purification method | Caprylic Acid/Ammonium Sulfate Precipitation |
Isotype | IgG2b | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
Calculated molecular weight |
70 kDa |
Observed molecular
weight |
42+60+70+110 kDa |
GenBank accession number |
BC005295 | Gene ID (NCBI) | 10605 |
Gene symbol | PAIP1 | Synonyms | PABP interacting protein 1, PAIP 1, PAIP1 |
Background
In initiation of translation in eukaryotes, binding of the small ribosomal subunit to mRNA requires recognition of the 5-prime cap structure by the cap-binding complex eIF4F. eIF4F consists of eIF4E, eIF4A, and eIF4G. Translation initiation is further regulated by the mRNA 3-prime poly(A) tail and the poly(A)-binding protein (PABC1). PAIP1 interacts with PABC1 and some eIF4 complexes [PMID:9548260]. It is a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs, and associates with EIF4A and PABPC1 may potentiate contacts between mRNA termini [PMID:11051545]. |