PAX8 Antibody
Product Details
Source | Mouse | Purification method | Protein A purification |
Isotype | IgG2b | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Calculated molecular weight |
48 kDa |
Observed molecular
weight |
48 kDa |
GenBank accession number |
BC001060 | Gene ID (NCBI) | 7849 |
Gene symbol | PAX8 | Synonyms | paired box 8, Paired box protein Pax 8, PAX8 |
PAX8 is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain and a paired-type homeodomain. It is expressed during organogenesis of the thyroid gland, kidney and Mullerian system. It is thought to regulate the expression of Wilms tumor suppressor (WT1) gene and mutations in PAX8 have been associated with Wilms tumor cells, thyroid and ovarian carcinomas. PAX8 is a useful marker in distinguishing ovarian carcinomas from mammary carcinomas (PMID: 18724243). PAX8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. |