phospho(409/410)-TDP43 Antibody

Product Details


Product Information
Source Mouse Purification method Protein G purification
Isotype IgG1 Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen Peptide Full name TAR DNA binding protein
Calculated molecular
weight
43 kDa Observed molecular
weight
45-50, 35 kDa
GenBank accession
number
NM_007375 Gene ID (NCBI) 23435
Gene symbol TARDBP Synonyms ALS10, phospho(409/410)-TDP43, TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43
Background

The TARDBP gene encodes the TDP-43 protein, initially found to repress HIV-1 transcription by binding TAR DNA. TDP-43 has since been shown to bind RNA as well as DNA, and have multiple functions in transcriptional repression, translational regulation and pre-mRNA splicing. For instance, it is reported to regulate alternate splicing of the CTFR gene. In 2006 Neumann et al. found that hyperphosphorylated, ubiquitinated and/or cleaved forms of TDP-43, collectively known as pathological TDP-43, play a major role in the disease mechanisms of ubiquitin-positive, tau- and alpha-synuclein-negative frontotemporal dementia (FTLD-U) and in amyotrophic lateral sclerosis (ALS). Proteintech’s 66318-1-Ig antibody is a phospho-dependent monoclonal antibody specifically recognizing phospho-TDP43 (409/410). It does not react with native TDP-43.

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