Prohibitin Antibody

Product Details


Product Information
Source Mouse Purification method Caprylic acid/ammonium sulfate precipitation
Isotype IgG1 Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Calculated molecular
weight
30 kDa Observed molecular
weight
30 kDa
GenBank accession
number
BC013401 Gene ID (NCBI) 5245
Gene symbol PHB Synonyms PHB, PHB1, prohibitin
Background

Prohibitin, also known as PHB, a member of the Band-7 family of proteins, is widely distributed in bacteria, plants, yeast, protozoa and mammals and is important in cell proliferation, differentiation and apoptosis (PMID: 20840588 ). This protein localizes to the inner membrane of mitochondria, where it acts as a chaperone protein, and is also found in the nucleus, where it negatively regulates transcription (PMID: 18558096). Recent study confirmed that the expression and distribution of PHB, which is a nuclear matrix protein, affect the apoptosis of HaCaT cells and its co-localization with specific gene products connected with cell apoptosis (PMID: 24402549).

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