Prohibitin Antibody
Product Details
Source | Mouse | Purification method | Caprylic acid/ammonium sulfate precipitation |
Isotype | IgG1 | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Calculated molecular weight |
30 kDa |
Observed molecular
weight |
30 kDa |
GenBank accession number |
BC013401 | Gene ID (NCBI) | 5245 |
Gene symbol | PHB | Synonyms | PHB, PHB1, prohibitin |
Prohibitin, also known as PHB, a member of the Band-7 family of proteins, is widely distributed in bacteria, plants, yeast, protozoa and mammals and is important in cell proliferation, differentiation and apoptosis (PMID: 20840588 ). This protein localizes to the inner membrane of mitochondria, where it acts as a chaperone protein, and is also found in the nucleus, where it negatively regulates transcription (PMID: 18558096). Recent study confirmed that the expression and distribution of PHB, which is a nuclear matrix protein, affect the apoptosis of HaCaT cells and its co-localization with specific gene products connected with cell apoptosis (PMID: 24402549). |