Product Areas
SIX2 Antibody
Product Details
Product Information
| Source | Mouse | Purification method | Protein A purification |
| Isotype | IgG2b | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
|
Calculated molecular weight |
291aa,32 kDa |
Observed molecular
weight |
37 kDa |
|
GenBank accession number |
BC024033 | Gene ID (NCBI) | 10736 |
| Gene symbol | SIX2 | Synonyms | Homeobox protein SIX2, Sine oculis homeobox homolog 2, SIX homeobox 2, SIX2 |
Background
The SIX proteins (sine oculis) are a family of homeodomain transcription factors that share a conserved DNA binding domain. Six members (Six1-Six6) of the Six gene family have been identified in mice and humans. SIX2, containing one homeobox DNA-binding domain, is highly expressed in fetal tissues but expression is limited in adult tissues. SIX2 may be involved in limb tendon and ligament development[PMID:21420949]. It has been previously shown that SIX2 is expressed in developing mesenchymal tissue including head and urogenital system at the time of overt midfacial and renal differentiation[PMID: 22282599]. |