Product Areas
SMN (Human-Specific) Antibody
Product Details
Product Information
Source | Mouse | Purification method | Protein A purification |
Isotype | IgG2a | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
Calculated molecular weight |
282aa,30 kDa |
Observed molecular
weight |
38 kDa |
GenBank accession number |
BC000908 | Gene ID (NCBI) | 6607 |
Gene symbol | SMN2 | Synonyms | C BCD541, Component of gems 1, FLJ76644, Gemin 1, SMN, SMN1, SMN1,SMN, SMN2, SMNC, SMNT, Survival motor neuron protein |
Background
The survival of motor neurons (SMN) genes are the disease genes of spinal muscular atrophy (SMA), a common motor neuron degenerative disease. The level of SMN protein correlates with phenotypic severity of SMA. SMA patients lack a functional SMN1 gene, but they possess an intact SMN2 gene, which though nearly identical to SMN1, is only partially functional, because a large majority of SMN2 transcripts lack exon 7, resulting in production of a truncated, less stable SMN protein. This antibody 60154-1-Ig is specific to human SMN2. It can't recognize mouse and rat SMN. |