TLE1 Antibody

Product Details


Product Information
Source Mouse Purification method Protein A purification
Isotype IgG2b Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Calculated molecular
weight
83 kDa Observed molecular
weight
85-95 kDa
GenBank accession
number
BC010100 Gene ID (NCBI) 7088
Gene symbol TLE1 Synonyms E(Sp1) homolog, ESG, ESG1, GRG1, TLE1
Background

Transducin-like enhancer protein 1(TLE1) is a transcriptional corepressor. It can bind to and regress expression of many transcription factors such as NFkB, which is mediated by FOXA2, CTNNB1 and TCF family member in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Expression of TLE1 is highest in skeletal muscle and liver, moderate in placenta, heart, kidney, and spleen, and weak in all other tissues including brain.

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