Product Areas
TLE3 Antibody
Product Details
Product Information
| Source: | Mouse | Purify: | Protein G purification |
| IsoType: | IgG1 | Storage: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles. |
Immunogen Information
|
Caculated Molecular Weight: |
772aa,83 kDa |
Observed Molecular
Weight: |
90 kDa |
| GenbankNo | BC015729 | GeneID: | 7090 |
| Symbol | TLE3 | Synonyms | ESG, ESG3, FLJ39460, GRG3, HsT18976, KIAA1547, TLE3 |
Background
TLE3, also named as KIAA1547 and ESG3, belongs to the WD repeat Groucho/TLE family. It is a transcriptional corepressor that binds to a number of transcription factors. It inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. TLE3 is a member of the transducin-like enhancer of split (TLE) family of proteins that have been implicated in the tumorgenesis and classification of sarcomas. It is a candidate biomarker of response to taxane therapy.(PMID:19309506 ) |