Product Areas
TLR4 Antibody
Product Details
Product Information
| Source | Mouse | Purification method | Protein A purification |
| Isotype | IgG2b | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
|
Calculated molecular weight |
839aa,96 kDa |
Observed molecular
weight |
100 kDa |
|
GenBank accession number |
BC117422 | Gene ID (NCBI) | 7099 |
| Gene symbol | TLR4 | Synonyms | ARMD10, CD284, hToll, TLR4, TOLL, toll like receptor 4 |
Background
TLR4, also named as CD284, belongs to the Toll-like receptor family. TLR4 cooperates with LY96 and CD14 to mediates the innate immune response to bacterial lipopolysaccharide (LPS). TLR4 acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Three alternatively spliced transcript variants that encode different protein isoforms have been described. |