Product Areas
TMEM106B Antibody
Product Details
Product Information
| Source | Mouse | Purification method | Protein G purification |
| Isotype | IgG1 | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
|
Calculated molecular weight |
31 kDa |
Observed molecular
weight |
~40 kDa |
|
GenBank accession number |
BC033901 | Gene ID (NCBI) | 54664 |
| Gene symbol | TMEM106B | Synonyms | FLJ11273, TMEM106B, transmembrane protein 106B |
Background
TMEM106B is a genetic risk factor for frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). Amyotrophic lateral sclerosis (ALS), like FTLD-TDP, is characterized by pathological TDP-43 inclusions. TMEM106B expression in the brain may be linked to mechanisms of disease in FTLD-TDP and risk alleles confer genetic susceptibility by increasing gene expression. |