Product Areas
MCL1L-specific Antibody
Product Details
Product Information
| Source: | Rabbit | Purify: | Antigen affinity purification |
| IsoType: | IgG | Storage: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles. |
Immunogen Information
| Immunogen: | Peptide | Full Name: | myeloid cell leukemia sequence 1 (BCL2-related) |
|
Caculated Molecular Weight: |
37 kDaa |
Observed Molecular
Weight: |
|
| GenbankNo | NM_182763 | GeneID: | 4170 |
| Symbol | MCL1 | Synonyms | EAT, Mcl 1, Mcl 1l, Mcl 1s Delta TM, MCL1, mcl1/EAT, MCL1L, MCL1S, TM |
Background
MCL-1 is an anti-apoptotic member of the Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line. Similar to BCL2 and BCL2L1, MCL1 can interact with BAX and/or BAK1 to inhibit mitochondria-mediated apoptosis. Mcl-1 is critical for the proliferation and survival of myeloma cells in vitro, and overexpression of Mcl-1 protein in myeloma cells is associated with relapse and short event-free survival in multiple myeloma patients. Recent studies show that MCL-1 is upregulated in numerous haematological and solid tumour malignancies. Therefore, MCL-1 has been suggested as a potential new therapeutic target. This antibody is specific to MCL1L isoform. |