Product Areas
XLF Antibody
Product Details
Product Information
Source | Rabbit | Purification method | Antigen affinity purification |
Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
Calculated molecular weight |
299aa,33 kDa |
Observed molecular
weight |
33 kDa |
GenBank accession number |
BC030986 | Gene ID (NCBI) | 79840 |
Gene symbol | NHEJ1 | Synonyms | FLJ12610, NHEJ1, Protein cernunnos, XLF, XRCC4 like factor |
Background
XRCC4-like factor (XLF), also known as Cernunnos and NHEJ1, is a protein encoded by the human NHEJ1 gene and an important repair factor for DNA double-strand breaks. NHEJ is a well-known mechanism for the repair of double-strand breaks (DSBs), a lethal type of DNA damage in mammalian cells. It basically utilizes a group of enzymes to take hold of the ends of a broken DNA molecule, create a bridge between them, and subsequently re-ligate the broken DNA molecule. |