Product Areas
YBX1 Antibody
Product Details
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
|
Calculated molecular weight |
324aa,36 kDa |
Observed molecular
weight |
50 kDa |
|
GenBank accession number |
BC010430 | Gene ID (NCBI) | 4904 |
| Gene symbol | YBX1 | Synonyms | BP 8, CBF A, CSDA2, CSDB, DBPB, DNA binding protein B, EFI A, Enhancer factor I subunit A, MDR NF1, NSEP 1, NSEP1, Y box binding protein 1, Y box transcription factor, YB 1, YB1, YBX1 |
Background
Y box binding protein 1(YBX1) is one of cis-acting elements which has a role in regulation of the expression of HLA class II genes. YBX1 is great of importance in regulation of PTP1B expression. It can bind to splice sites mediate pre-mRNA alternative splicing regulation. Also it involves in the regulation of translation by modulation of the interaction between the mRNA and eukaryotic initiation factors. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation |