ZNF354A Antibody
Product Details
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
|
Calculated molecular weight |
69 kDa |
Observed molecular
weight |
69 kDa |
|
GenBank accession number |
BC047105 | Gene ID (NCBI) | 6940 |
| Gene symbol | ZNF354A | Synonyms | EZNF, HKL1, KID 1, KID1, TCF 17, TCF17, Transcription factor 17, zinc finger protein 354A, Zinc finger protein eZNF, ZNF354A |
ZNF354A, also called EZNF, KID-1 or TCF17, belongs to the Kruppel C2H2-type zinc-finger family of proteins that contain KRAB domains and act as transcriptional regulators. Expressed primarily in the adult kidney, ZNF354A is a transcriptional repressor that plays a role in late renal development and is suppressed after renal ischemia. The N-terminus of ZNF354A contains the KRAB domain which confers transcriptional repressor activity, while the C-terminus contains multiple Cys2His2-zinc fingers. ZNF354A is located in the nucleolus and is thought to specifically influence development of the proximal tubule by shutting off dispensable or inhibitory genes. Reduced ZNF354A expression prevents proper cell differentiation and may, therefore, be implicated in renal carcinoma. |