Product Areas
MYOC Antibody
Product Details
Product Information
| Source | Mouse | Purification method | Protein A purification |
| Isotype | IgG2a | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
|
Calculated molecular weight |
57 kDa |
Observed molecular
weight |
50-57 kDa |
|
GenBank accession number |
BC029261 | Gene ID (NCBI) | 4653 |
| Gene symbol | MYOC | Synonyms | GLC1A, GPOA, JOAG, JOAG1, MYOC, myocilin, TIGR |
Background
Myocilin (MYOC), also known as TIGR or GLC1A, is a secreted glycoprotein of the olfactomedin family, originally identified in trabecular meshwork cells after prolonged treatment with glucocorticoids, and, independently, in the retina (PMID: 9176893; 9169133). It may participate in the obstruction of fluid outflow in the trabecular meshwork. Defects in MYOC are the cause of primary open angle glaucoma (POAG) (PMID: 21709622). |