Product Areas
PAI-1 Antibody
Product Details
Product Information
| Source | Mouse | Purification method | Protein G purification |
| Isotype | IgG1 | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
|
Calculated molecular weight |
402aa,45 kDa |
Observed molecular
weight |
50 kDa |
|
GenBank accession number |
BC010860 | Gene ID (NCBI) | 5054 |
| Gene symbol | SERPINE1 | Synonyms | PAI, PAI 1, PAI1, PLANH1, Serpin E1, SERPINE1 |
Background
SERPINE1, also named as Plasminogen activator inhibitor type 1 (PAI-1), is a member of the serine protease inhibitor (SERPIN) superfamily. PAI-1 is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. |