Product Areas
Pre-IL18 Antibody
Product Details
Product Information
| Source: | Mouse | Purify: | Caprylic acid/ammonium sulfate precipitation |
| IsoType: | IgG2b | Storage: | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles. |
Immunogen Information
|
Caculated Molecular Weight: |
193aa,22 kDa |
Observed Molecular
Weight: |
24 kDa |
| GenbankNo | BC007461 | GeneID: | 3606 |
| Symbol | IL18 | Synonyms | Iboctadekin, IFN gamma inducing factor, IGIF, IL 1 gamma, IL 18, IL 1g, IL18, IL1F4, Interleukin 1 gamma, Interleukin 18 |
Background
IL18, is a proinflammatory cytokine involved in the development of Th1 cells and in immune response. It can stimulate the NK cells and certain T cells to release interferon gamma which plays an important role in activating the macrophages or other cells. IL18 has been demonstrated to have the potential to enhance Fas ligand-mediated cytotoxicity, which is increased in PE and regulates placental apoptosis. IL18 is synthesized as a 24 kDa precursor and then cleaved into a biologically activate 18 kDa form. |