Product Areas
SMN (Human,Mouse,Rat) Antibody
Product Details
Product Information
| Source: | Mouse | Purify: | Protein A purification |
| IsoType: | IgG2b | Storage: | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles. |
Immunogen Information
|
Caculated Molecular Weight: |
282aa,30 kDa |
Observed Molecular
Weight: |
38 kDa |
| GenbankNo | BC000908 | GeneID: | 6607 |
| Symbol | SMN2 | Synonyms | C BCD541, Component of gems 1, FLJ76644, Gemin 1, SMN, SMN1, SMN1,SMN, SMN2, SMNC, SMNT, Survival motor neuron protein |
Background
The survival of motor neurons (SMN) genes are the disease genes of spinal muscular atrophy (SMA), a common motor neuron degenerative disease. The level of SMN protein correlates with phenotypic severity of SMA. SMA patients lack a functional SMN1 gene, but they possess an intact SMN2 gene, which though nearly identical to SMN1, is only partially functional, because a large majority of SMN2 transcripts lack exon 7, resulting in production of a truncated, less stable SMN protein. This antibody 60154-2-Ig can recognize human,mouse and rat SMN gene. |