Product Areas
UBE2C Antibody
Product Details
Product Information
| Source: | Mouse | Purify: | Protein A purification |
| IsoType: | IgG1 | Storage: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles. |
Immunogen Information
|
Caculated Molecular Weight: |
179aa,20 kDa |
Observed Molecular
Weight: |
20kD |
| GenbankNo | BC016292 | GeneID: | 11065 |
| Symbol | UBE2C | Synonyms | dJ447F3.2, UBCH10, UBE2C, Ubiquitin carrier protein C, Ubiquitin protein ligase C |
Background
UBE2C(Ubiquitin-conjugating enzyme E2 C) is also known as UBCH10 and belongs to the ubiquitin-conjugating enzyme family. It is highly expressed in a variety of human primary tumors, and it is able to promote cell proliferation and malignant transformation(PMID:18703417). UBE2C, along with the E3 ligase of the anaphasepromoting complex (APC), catalyzes the ubiquitination of mitotic cyclins A and B, as well as securin. UBE2C is essential for cell cycle progression, and mutation of its active site cysteine confers a dominant-negative phenotype(PMID:17217624). |