Zyxin Antibody

Product Details


Product Information
Source: Mouse Purify: Protein G purification
IsoType: IgG1 Storage: PBS with 0.0.2% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles.
Immunogen Information
Caculated Molecular
Weight:
80 kDa Observed Molecular
Weight:
78kd
GenbankNo BC008743 GeneID: 7791
Symbol ZYX Synonyms ESP 2, HED 2, ZYX, zyxin, Zyxin 2
Background

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin (ZYX) is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles.

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