Lin28A-specific Antibody
Product Details
| Source: | Rabbit | Purify: | Antigen affinity purification |
| IsoType: | IgG | Storage: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles. |
| Immunogen: | Peptide | Full Name: | lin-28 homolog (C. elegans) |
|
Caculated Molecular Weight: |
23 kDa |
Observed Molecular
Weight: |
28 kDa |
| GenbankNo | NM_024674 | GeneID: | 79727 |
| Symbol | LIN28 | Synonyms | CSDD1, FLJ12457, LIN 28, lin 28 homolog (C. elegans), Lin 28A, LIN28, Lin28A, Protein lin 28 homolog A, ZCCHC1 |
LIN28 is one of the four key human factors (OCT4, SOX2, NANOG and LIN28) used to reprogram human fibroblasts to an embryonic stem (ES) cell-like state known as the induced pluripotent stem (Ips) cell. Lin28 is a marker of undifferentiated human embryonic stem cells and a cytoplasmic Mrna-binding protein that binds to and enhances the translation of the IGF2 Mrna. LIN28 has also been shown to bind to the let-7 pre-miRNA and block production of the mature let-7 microRNA in mouse embryonic stem cells. Affinity purified rabbit anti-LIN28 can be used to demonstrate pluripotency of ES and Ips cells, and to detect LIN28 transgene expression in the process of reprogramming. This antibody is a rabbit polyclonal antibody raised against a peptide mapping within human LIN28.This antibody recognize Lin28A specifically. |